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Technical University of Munich

Christian Mertes

Positions

2021 - present Postdoc in the Chair of Computational Molecular Medicine and coordinator of the GHGA workflow workstream, TUM, Germany
2020 Visitor at Stanford University in the Montgomery lab
2017 - 2018 Visitor at Stanford University in the Steinmetz lab
2014 - present PhD student and system administrator in the Chair of Computational Molecular Medicine, TUM, Germany
2011 - 2016 Volleyball coach of a "mixed-league" team
2014 Master Thesis in the Computational Genomics group of the Gene Center, Munich, Germany
2012 - 2014 Tutor "Programmierpraktikum", LMU, Munich, Germany
2010 - 2011 Research assistant, TUM, Germany
2009 - 2010 Tutor "Informatics I", TUM, Germany

Education

2021   Dr. rer. nat. by the Chair of Computational Molecular Medicine, TUM, Germany
2011 - 2015   M.Sc in Bioinformatics, TUM / LMU, Munich, Germany
2008 - 2011   B.Sc in Bioinformatics, TUM / LMU, Munich, Germany

Publications

  • Tina Meißgeier, Melanie Kappelmann-Fenzl, Sebastian Staebler, Ata Jadid Ahari, Christian Mertes, Julien Gagneur, Lisa Linck-Paulus, Anja Katrin Bosserhoff. Splicing control by PHF5A is crucial for melanoma cell survival. Cell Proliferation, 2024, PMID: 39212334

  • Vicente A. Yépez@, Nicholas H. Smith, Ines Scheller, Julien Gagneur, Christian Mertes@. Predicting molecular events underlying rare diseases using variant annotation, aberrant gene expression events, and human phenotype ontology. Research Square, 2023

  • Felix Brechtmann, Thibault Bechtler, Shubhankar Londhe, Christian Mertes, and Julien Gagneur. Evaluation of input data modality choices on functional gene embeddings. NAR Genomics and Bioinformatics, 2023, PMID: 37942285

  • Ines Scheller, Karoline Lutz, Christian Mertes, Vicente A. Yépez@, Julien Gagneur@. Improved detection of aberrant splicing and the Intron Jaccard Index. The American Journal of Human Genetics, 2023, PMID: 38006880 Sharedlt Link

  • Nils Wagner, Muhammed H. Çelik, Florian R. Hölzlwimmer, Christian Mertes, Holger Prokisch, Vicente A. Yépez, Julien Gagneur. Aberrant splicing prediction across human tissues. Nature Genetics, 2023, PMID: 37142848
  • Vicente A. Yépez*, Mirjana Gusic*, ..., Christian Mertes, Nicholas H. Smith, ..., Michaela F. Müller, ..., Julien Gagneur@, Holger Prokisch@. Clinical implementation of RNA sequencing for Mendelian disease diagnostics. Genome Medicine, 2022, PMID: 35379322
  • Robert Kopajtich, ..., Ines Scheller, ..., Christian Mertes, ..., Vicente Yépez, ..., Julien Gagneur, Holger Prokisch. Integration of proteomics with genomics and transcriptomics increases the diagnostic rate of Mendelian disorders. medRxiv, 2021
  • Yogesh Singh, ..., Julien Gagneur, ..., Christian Mertes, ..., Inti Alberto De La Rosa Velázquez. SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells. Heliyon, 2021, PMID: 34075347 Sharedlt link.
  • Benjamin Krämer, ..., Julien Gagneur, ..., Christian Mertes, ..., Janne Vehreschild. Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. Immunity, 2021, PMID: 34592166 Sharedlt link.
  • Christian Mertes*, Ines Scheller*, Vicente A. Yépez, Muhammed H. Çelik, ..., Holger Prokisch, Julien Gagneur. Detection of aberrant splicing events in RNA-Seq data with FRASER. Nature Communications, 2021, PMID: 33483494 Sharedlt link.
  • Vicente A. Yépez, Christian Mertes, Michaela F. Müller, Daniela S. Andrade, Leonhard Wachutka, ..., Ines Scheller, ..., Julien Gagneur. Detection of aberrant events in RNA-seq data. Nature Protocols , 2021, PMID: 33462443 Sharedlt link.
  • Felix Brechtmann*, Agne Matuseviciute*, Christian Mertes*, Vicente A Yepez, Ziga Avsec, ..., Julien Gagneur, OUTRIDER: A statistical method for detecting aberrantly expressed genes in RNA sequencing data, AJHG, 2018, PMID: 30503520
  • Beate Hagl,..., Christian Mertes, ..., Julien Gagneur, ..., Ellen D. Renner, Somatic alterations compromised molecular diagnosis of DOCK8 hyper-IgE syndrome caused by a novel intronic splice site mutation., Scientific Reports 2018 Nov 13;8(1):16719, PMID: 30425284
  • Laura S Kremer*, Daniel M Bader*, Christian Mertes, ..., Julien Gagneur@, and Holger Prokisch@, Genetic diagnosis of Mendelian disorders via RNA sequencing, Nature communications, 2017. PMID: 28604674
  • Maximilian Witzel,..., Christian Mertes, Julien Gagneur, ..., Christoph Klein, Chromatin remodelling factor SMARCD2 regulates transcriptional networks controlling early and late differentiation of neutrophil granulocytes, Nature Genetics, 2017. PMID: 28369036
  • Samira Ait-El-Makdem, ..., Ziga Avsec, Christian Mertes, ..., Julien Gagneur, ..., Véronique Paquis-Flucklinger, Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy, AJHG, 2017, Jan 5. PMID: 27989324
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